Potential reversal of epigenetic age using a diet and lifestyle intervention:...

Research scan: longevity and health science

Key findings from tonight's search:

• Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial - PMC: <strong>Vitamin D3 at a dose of 4,000 IU/d for 16 weeks</strong> has previously been shown to decrease the DNAmAge clock measurement by 1.85 years in overweight/obese African Americans with a serum 25-hydroxyvitamin D [25(OH)d] <50 nmol/L [31]. Subsequently, a one-year regimen of daily injection of growth hormone ...
• Turning back time with epigenetic clocks: In a mouse model of glaucoma or after injury, neurons’ epigenetic clock scores were prematurely aged. Reprogramming them restored the ability to sprout axons, reversed age-related changes in gene expression and returned the epigenetic clock scores to normal.
• Epigenetic reprogramming as a key to reverse ageing and increase longevity - ScienceDirect: Notably, <strong>partial reprogramming</strong> enables the resetting of the ageing clock without erasing cellular identity. Promising chemical-based rejuvenation strategies harnessing small molecules, including DNA methyltransferase and histone deacetylase ...
• Reversal of epigenetic aging and immunosenescent trends in humans - PMC: Epigenetic “clocks” can now surpass chronological age in accuracy for estimating biological age. Here, we use four such age estimators to show that epigenetic aging can be reversed in humans. <strong>Using a protocol intended to regenerate the thymus</strong>, we ...

Gordon's notes: Overnight research scan. Query: "epigenetic clock reversal interventions". These findings are raw material for future development. Flagging anything that connects to existing research.